Evaluation of Serum Ferritin as Prognostic Marker in Acute Hemorrhagic Stroke
Keywords:Haemorrhagic Stroke, Prognostic Markers, Serum Ferritin
Acute neurological dysfunction caused by a stroke or cerebrovascular accident can have either an ischemic or hemorrhagic cause. A blood artery rupture that results in bleeding into the brain causes hemorrhagic stroke. There are two types of hemorrhagic stroke: subarachnoid haemorrhage (SAH), and intracerebral haemorrhage (ICH) which is more prevalent. High mortality and significant morbidity are linked to hemorrhagic stroke.1 Serum ferritin levels were one of 61 independent predictive molecular biomarkers evaluated in the immediate phase following a hemorrhagic stroke that could predict motor functional recovery.2 The goal of this study was to identify the serum ferritin level at admission time as a predictive prognostic biomarker in acute hemorrhagic stroke. This cross-sectional observational study was conducted on 72 patients hospitalized to the medical intensive care unit between October and December in a single institution. 72 patients who were admitted to the medical ICU between October 2020 and March 2022 for their first episode of stroke and who were clinically and radiologically determined to have primary intra cerebral haemorrhage were included in this single-center, hospital-based, cross-sectional observational study. The study participants were divided into three groups according to their mRS scores: those with a good prognosis (mRS = 0-2), those with a poor prognosis (mRS = 3-5), and those with the worst prognostic outcome of death (mRS = 6). Also, patients were divided into three groups according to the GCS Score change: better, deteriorated, and died. In addition to being compared between research groups, ferritin levels were also linked to ICH severity indices. Low GCS and high mRS scores were related with high serum ferritin concentrations, indicating the severity of the stroke.